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TECHNOLOGY

Core technology

Paradigm shift in the biopharmaceutical manufacturing
The MIDAS™ system, a next-generation purification platform, is an innovative technology for purifying biopharmaceutical in a column-free manner based on inducer-dependent self-assembly.
Traditional protein purification system
  • Use of expensive resins/columns
  • Time-consuming
  • Complexity of purification process
  • Use of expensive affinity resins/columns and need for operating equipment (facilities).
  • Chemical cutting: Use of strong acids and toxic chemicals (safety issues).
  • Diversity and complexity of purification process.
  • Harsh elution conditions affecting antibody activity.
  • Purification is extremely time-consuming.
  • Use of large-volume buffers and generation of substantial waste.
  • Contamination with non-specific proteins.
  • Limitations in the host range of some purification tags.
  • Issues with the size of the purification tag.
  • Cross-use of resin/columns is manufacturing lines is not possible, etc.
  • Cleavage and removal of purification tags: Additional processes, time and costs incurred.
To Be
Next-generation MIDAS™ purification platform
  • Paradigm shift in purification methods
    • Purification based on density and size.
  • Very easy & simple
    • Low-speed centrifugation or filtration.
    • Simplification of purification process.
  • Very low cost
    • Columns(x), miniaturization of equipment/facilities.
    • Manufacturing costs: reduced to a minimum or about 1/200.
  • Extremely rapid
    • ~30 minutes
    • Purification time reduced to about 1/50.
  • High purity & yield
    • ≥98% & ≥90%
  • Smart cut & removal
    • Smart eraser system
    • Efficient removal of tags
  • Safe system
    • Catalysts whose safety is guaranteed.
    • Minimization of waste.

Excellence and competitiveness of the MIDAS™ purification platform.

  • Downstream costs reduced to about 1/200

    Super-gap price competitiveness.
    • A low-cost system that eliminates the need for expensive purification columns and large-scale purification equipment/facilities.
    • Excellent scalability achieved by overcoming scale-up limitations in the purification process due to high costs.
    • Minimization of the UF/DF process which is for an exchange and enrichment of buffers.

  • Time taken reduced to about 1/40

    Competitive speed in manufacturing/supply
    • Traditional protein purification process: typically takes 1 to 4 days.
    • Minimization of UF/DF processes through high-concentration recovery methods.
    • Extremely rapid system

  • Yield : ≥ 90%
    Purity : ≥ 98%

    High yield&purity
    • The MIDAS™ system exhibit high sensitivity/selectivity to specific inducers.
    • Better efficiency and purity compared to traditional purification methods.